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Duloxetine 30 mg capsules 1-3 daily for 12 weeks in the treatment of adult patients with schizophrenia. Randomised placebo, fluoxetine, the combination of fluoxetine and amisulpride, the combination of fluoxetine, venlafaxine, and imipramine were also tested. Intervention: Efficacy Baseline efficacy analyses, according to the treatment group assignment, were conducted at weeks 8 (primary end point), 12, and 16. The analyses included all enrolled patients. Comparison of efficacy was evaluated according to outcome using a binary two-tailed, repeated measures analysis of variance (ANOVA). Treatment efficacy analyses were also performed according to baseline scores on measures of depressive and anxious symptoms (as well as the primary outcome measure, overall relapse severity). Results: Overall, 481 (33%) patients were randomized. Treatment efficacy was higher on both the primary and secondary outcome measures on visits 8 and 16 than at baseline no significant differences [F(1, 38) = 1.15, p 0.25, η²(2) 0.03]. Baseline analyses found a significantly shorter initial period to treatment discontinuation among patients Pantozol rezeptfrei österreich on fluoxetine (P = 0.02) and a faster decline to efficacy among the fluoxetine (P < 0.001) and amisulpride = 0.01) patients than among those on other treatments [F(2, 208) = 6.08, p 0.004, η²(2) 0.31 and F(2, 208) = 7.05, p 0.04, η²(2) 0.31]. In addition, patients treated with fluoxetine and amisulpride had a shorter time to first relapse from the secondary outcome measure on weeks 8 through 16 than those on other treatments [F(2, 208) = 8.01, p 0.004, η²(2) 0.22 and F(2, 208) = 8.03, p 0.004, η²(2) 0.22, respectively]. No significant differences were found between the treatments when comparing time to first relapse in the Acure shampoo australia second half of study on weeks 8 Is diflucan sold over the counter in canada through 16. Treatment differences were evident at week 12. In the fluoxetine group, a more rapid reduction in depressive symptoms on the Hospital Anxiety and Depression Scale (HADS)-revised was observed [t(68) = −3.16, p 0.005, η²(2) 0.13], with a decrease in mean HADS scores from 80.1 to 62.2 on week 12. This effect was evident at week 16, demonstrating that the amisulpride treatment was effective at reducing depressive symptoms that had developed over weeks 8 and 16 (P < 0.001 for both). As expected, there were no treatment differences among patients on the other treatments in terms of HADS scores at week 12. However, mean scores of HADS for patients on fluoxetine and amisulpride in the second half of study differed [F(2, 208) = 7.13, p 0.004, η²(2) 0.31]. Similar duloxetine generic prices results were obtained for HADS scores on week 8 through 16: a similar mean reduction was observed in patients on both fluoxetine and amisulpride [F(2, 204) = 3.44, p 0.023, η²(2) 0.09], but a significantly lesser HADS change was observed among patients on venlafaxine versus amisulpride [F(1, 98) = 6.33, p 0.003, η²(2)
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